The scope of the research may be extended to cases of scarring in the liver, severe kidney diseases, fibrosis caused by heart attacks, and general aging. A completely new outlook is available for the experts of the respective fields to work on.
A groundbreaking cure for Crohn’s disease which has recently been brought to the fore may save the victims, from severe symptoms of the disease like diarrhea and excruciating pain. The persistence of these crippling symptoms often needs to repeat surgery on the same delicate, damaged part of our body. Research to the rescue, if we may say so. Read on about this groundbreaking cure for Crohns disease.
Breakthrough Therapy for Crohn’s Disease
1What is Crohn’s Disease
Crohn’s disease as a condition is still mostly incurable. These eruptions to the intestines affect countless people the world over, every year, with the number close to 115,000 in the UK alone. The symptoms are grievous to say the least. Surgeries are performed on the patients, time and again, when symptoms such as diarrhea, intense abdominal cramps and fatigue persist, even after administration of alleviating drugs.
The damaged section of the gut is often done away with, through operation, and the connections accordingly established. Only that the accordance with this particular case is not a very well suited situation to be at. Postoperative recovery may not be a comfortable or assured process. Once the disease infects the person, the symptoms may lay dormant for long periods, before suddenly showing up in all severity.
The persistence of these crippling symptoms often needs to repeat surgery on the same delicate, damaged part of our body. Research to the rescue, if we may say so.
However scientist are of the belief that drugs are already available on the shelf, may or may not be there in the market. These pharmaceutical remedies, if made available in the commercial market may be used to prevent the flaring up of the inflammations that lead to fibrosis, or the scarring of the tissues of the intestine, which eventually causes the blockages that we know as Crohn’s disease.
2The Recent Research
The researchers on the subject under discussion, infected lab mice with a kind of enteric bacteria which could duplicate the symptoms of Crohns disease in the specimen. The researchers discovered that a certain gene mutation in the animal prevented some among them from developing fibrosis. The above mentioned mutation, in case of the mice turned off a certain hormone receptor, which otherwise triggered some parts of the body’s immune system, the action been inflammatory in nature.
The researchers are of the belief, that it was this reaction of the immune system which brought about the fibrosis. Fibrosis in fact is nothing more that these eruptive cells which trigger other cells into producing this scarred matrix. The very cells, which drives the whole operation, seemed to have been identified by the researchers this rime around. The defective gene, which stimulated the process has been recognized to be the hormone receptor. Moreover a way by which these cells could be targeted has been recognized. A way to mellow down the effects of the inflammatory cells, and thus prevent fibrosis from occurring.
The only thing required might just be the availability of the medication in the commercial market. The medication available may have the capability of completely shutting out this hormone receptor, which brings about the inflammation of the cells. Thus fibrosis could be prevented from occurring.
Also Read: Treatment of Crohn’s Disease through Diet
The recent findings may come in useful for the treatment of other types of fibrosis as well. The scope of the research may be extended to cases of scarring in the liver, severe kidney diseases, fibrosis caused by heart attacks, and general aging. A completely new outlook is available for the experts of the respective fields to work on.
Also Read: Impact of Crohn’s Disease on the Brain
Fibrosis is a responsive process which may occur not just because of chronic inflammations but also because of natural aging. This process if reversed, may lead to the promotion of regeneration, rather than embracing disintegration. For instance, cirrhosis of the liver is a condition when the healthy tissues are overcome by scars. Similar are the circumstances with the muscles of the heart in case of a heart attack.
Further research needs to conduct on lab mice, to get a clarity on the subject of medication that may be used for the respective conditions. The researchers are of the belief that the breakthrough made in the subject may lead to treatment of a number of age related problems experienced by mankind. As far as Crohn’s disease is concerned, the agony inflicted upon by the disease has been proclaimed to be more excruciating than childbirth.
Also Read: Types of Crohn’s Disease